Drug interactions
Duloxetine + Ondansetron
Severity: Moderate
Duloxetine and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, so using them together may increase the risk of serotonin syndrome, although cases are uncommon. Symptoms include agitation, tremor, clonus, sweating and fever.
What this interaction means in plain words
Duloxetine and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Possible additive serotonergic effects from 5-HT3 antagonism together with serotonin-norepinephrine reuptake inhibition.
What to do
Monitor for neuromuscular and autonomic signs of serotonin syndrome when starting or increasing doses. Stop the combination and give supportive care if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Ondansetron?
MediHelp rates the interaction as moderate. Duloxetine and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, so using them together may increase the risk of serotonin syndrome, although cases are uncommon. Symptoms include agitation, tremor, clonus, sweating and fever.
How serious is the interaction between Duloxetine and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuromuscular and autonomic signs of serotonin syndrome when starting or increasing doses. Stop the combination and give supportive care if symptoms develop.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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