Drug interactions
Duloxetine + Oxycodone
Severity: Moderate
Duloxetine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine moderately inhibits CYP2D6, but oxycodone is mainly cleared by CYP3A4, so the pharmacokinetic effect is probably small. Both drugs have serotonergic activity, so serotonin syndrome is a rare possibility and CNS effects may be additive.
What this interaction means in plain words
Duloxetine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
CYP2D6 inhibition by duloxetine and additive serotonergic activity.
What to do
Monitor for serotonin toxicity (agitation, tremor, hyperthermia, clonus) and for changes in analgesic response or sedation, especially at initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Oxycodone?
MediHelp rates the interaction as moderate. Duloxetine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine moderately inhibits CYP2D6, but oxycodone is mainly cleared by CYP3A4, so the pharmacokinetic effect is probably small. Both drugs have serotonergic activity, so serotonin syndrome is a rare possibility and CNS effects may be additive.
How serious is the interaction between Duloxetine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity (agitation, tremor, hyperthermia, clonus) and for changes in analgesic response or sedation, especially at initiation or dose changes.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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