Drug interactions
Duloxetine + Ozanimod
Severity: Major
Duloxetine and Ozanimod: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, and combining it with drugs that increase serotonin or norepinephrine such as duloxetine raises concern for hypertensive crisis or serotonin syndrome. Clinical data are limited, but labeling advises against the combination.
What this interaction means in plain words
Duloxetine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites adds to duloxetine's serotonin and norepinephrine reuptake inhibition.
What to do
Avoid concurrent use where possible and choose alternative therapy. If used, monitor blood pressure and watch for serotonin syndrome symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Duloxetine with Ozanimod?
MediHelp rates the interaction as major. Duloxetine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolites inhibit MAO-B in vitro, and combining it with drugs that increase serotonin or norepinephrine such as duloxetine raises concern for hypertensive crisis or serotonin syndrome. Clinical data are limited, but labeling advises against the combination.
How serious is the interaction between Duloxetine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose alternative therapy. If used, monitor blood pressure and watch for serotonin syndrome symptoms.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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