Drug interactions
Duloxetine + Pregabalin
Severity: Moderate
Duloxetine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes dose-related drowsiness, dizziness and cognitive slowing, and duloxetine can add to these effects. Respiratory depression is uncommon alone but is a concern with additional CNS depressants or in frail patients.
What this interaction means in plain words
Duloxetine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Titrate gradually and monitor for sedation, dizziness and falls. Avoid adding other sedatives and adjust pregabalin for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Duloxetine with Pregabalin?
MediHelp rates the interaction as moderate. Duloxetine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin causes dose-related drowsiness, dizziness and cognitive slowing, and duloxetine can add to these effects. Respiratory depression is uncommon alone but is a concern with additional CNS depressants or in frail patients.
How serious is the interaction between Duloxetine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate gradually and monitor for sedation, dizziness and falls. Avoid adding other sedatives and adjust pregabalin for renal function.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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