Drug interactions
Duloxetine + Ranolazine
Severity: Minor
Duloxetine and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP2D6 inhibitor and may modestly raise duloxetine concentrations. This could increase duloxetine adverse effects such as nausea, dizziness, raised blood pressure or serotonergic symptoms. The effect is usually small.
What this interaction means in plain words
Duloxetine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine weakly inhibits CYP2D6, reducing duloxetine metabolism.
What to do
No routine dose change is needed. Watch for duloxetine adverse effects, particularly blood pressure increases and dizziness, and adjust the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Duloxetine and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Ranolazine?
MediHelp rates the interaction as minor. Duloxetine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a weak CYP2D6 inhibitor and may modestly raise duloxetine concentrations. This could increase duloxetine adverse effects such as nausea, dizziness, raised blood pressure or serotonergic symptoms. The effect is usually small.
How serious is the interaction between Duloxetine and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for duloxetine adverse effects, particularly blood pressure increases and dizziness, and adjust the dose if they occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
