Drug interactions
Duloxetine + Rizatriptan
Severity: Moderate
Duloxetine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using an SNRI with a triptan may increase serotonergic activity, with a small risk of serotonin syndrome. Most patients tolerate the combination, but symptoms such as agitation, tremor and hyperthermia need prompt recognition.
What this interaction means in plain words
Duloxetine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition and 5-HT1B/1D agonism.
What to do
Counsel on warning symptoms and avoid exceeding recommended triptan doses. Stop both drugs and give supportive care if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Duloxetine with Rizatriptan?
MediHelp rates the interaction as moderate. Duloxetine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using an SNRI with a triptan may increase serotonergic activity, with a small risk of serotonin syndrome. Most patients tolerate the combination, but symptoms such as agitation, tremor and hyperthermia need prompt recognition.
How serious is the interaction between Duloxetine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on warning symptoms and avoid exceeding recommended triptan doses. Stop both drugs and give supportive care if serotonin syndrome is suspected.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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