Drug interactions
Duloxetine + Rucaparib
Severity: Moderate
Duloxetine and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP1A2 inhibitor and duloxetine is primarily cleared by CYP1A2. Duloxetine plasma levels may increase, raising the risk of nausea, dizziness, somnolence and blood pressure elevation.
What this interaction means in plain words
Duloxetine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP1A2-mediated duloxetine metabolism by rucaparib.
What to do
Monitor for duloxetine adverse effects and lower the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Duloxetine with Rucaparib?
MediHelp rates the interaction as moderate. Duloxetine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP1A2 inhibitor and duloxetine is primarily cleared by CYP1A2. Duloxetine plasma levels may increase, raising the risk of nausea, dizziness, somnolence and blood pressure elevation.
How serious is the interaction between Duloxetine and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and lower the dose if they occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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