Drug interactions
Duloxetine + Stiripentol
Severity: Moderate
Duloxetine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP1A2 and CYP2D6, both involved in duloxetine clearance. Duloxetine exposure may therefore rise, with more nausea, dizziness and sedation.
What this interaction means in plain words
Duloxetine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibition of CYP1A2 and CYP2D6 metabolism of duloxetine.
What to do
Monitor for duloxetine adverse effects and adjust the dose if needed. Also review overall CNS sedation when stiripentol is used with other antiseizure drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Duloxetine with Stiripentol?
MediHelp rates the interaction as moderate. Duloxetine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes including CYP1A2 and CYP2D6, both involved in duloxetine clearance. Duloxetine exposure may therefore rise, with more nausea, dizziness and sedation.
How serious is the interaction between Duloxetine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and adjust the dose if needed. Also review overall CNS sedation when stiripentol is used with other antiseizure drugs.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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