Drug interactions
Dutasteride + Itraconazole
Severity: Minor
Dutasteride and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and may increase dutasteride concentrations. Given dutasteride's tolerability, clinically significant toxicity is unlikely.
What this interaction means in plain words
Dutasteride and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, reducing dutasteride clearance.
What to do
No dose change is routinely needed. Monitor for sexual or other dutasteride adverse effects during long-term co-administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Dutasteride with Itraconazole?
MediHelp rates the interaction as minor. Dutasteride and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole is a strong CYP3A4 inhibitor and may increase dutasteride concentrations. Given dutasteride's tolerability, clinically significant toxicity is unlikely.
How serious is the interaction between Dutasteride and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for sexual or other dutasteride adverse effects during long-term co-administration.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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