Drug interactions
Dutasteride-tamsulosin + Givosiran
Severity: Moderate
Dutasteride-tamsulosin and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, which may increase tamsulosin exposure. This may increase hypotension and dizziness.
What this interaction means in plain words
Dutasteride-tamsulosin and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran decreases CYP2D6 activity, reducing tamsulosin metabolism.
What to do
Monitor blood pressure and orthostatic symptoms and consider lowering the tamsulosin dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Givosiran?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, which may increase tamsulosin exposure. This may increase hypotension and dizziness.
How serious is the interaction between Dutasteride-tamsulosin and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms and consider lowering the tamsulosin dose if they occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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