Drug interactions
Edoxaban + Posaconazole
Severity: Moderate
Edoxaban and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits P-glycoprotein, which can increase edoxaban absorption and exposure and raise the risk of bleeding. The effect is moderate with strong P-gp inhibitors.
What this interaction means in plain words
Edoxaban and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
P-glycoprotein inhibition increases edoxaban absorption and reduces its efflux.
What to do
For DVT/PE treatment, labeling advises a reduced edoxaban dose of 30 mg daily with some strong P-gp inhibitors; for atrial fibrillation no adjustment is recommended. Monitor for bleeding in all cases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Posaconazole?
MediHelp rates the interaction as moderate. Edoxaban and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits P-glycoprotein, which can increase edoxaban absorption and exposure and raise the risk of bleeding. The effect is moderate with strong P-gp inhibitors.
How serious is the interaction between Edoxaban and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For DVT/PE treatment, labeling advises a reduced edoxaban dose of 30 mg daily with some strong P-gp inhibitors; for atrial fibrillation no adjustment is recommended. Monitor for bleeding in all cases.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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