Drug interactions
Edoxaban + Progesterone
Severity: Minor
Edoxaban and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone has been listed as a possible P-glycoprotein inhibitor that could increase edoxaban exposure. Clinical significance is uncertain, and any rise in exposure is likely modest compared with strong inhibitors.
What this interaction means in plain words
Edoxaban and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Edoxaban belongs to Cardiovascular; Progesterone belongs to Endocrine.
Why it happens
Progesterone may inhibit P-glycoprotein efflux, which could slightly raise edoxaban levels.
What to do
No dose change is generally required. Watch for signs of bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Progesterone?
MediHelp rates the interaction as minor. Edoxaban and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone has been listed as a possible P-glycoprotein inhibitor that could increase edoxaban exposure. Clinical significance is uncertain, and any rise in exposure is likely modest compared with strong inhibitors.
How serious is the interaction between Edoxaban and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Watch for signs of bleeding.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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