Drug interactions
Edoxaban + Ticlopidine
Severity: Major
Edoxaban and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits platelet aggregation, and with edoxaban the bleeding risk rises. Ticlopidine also carries a risk of blood dyscrasias such as neutropenia and thrombocytopenia, which may further worsen bleeding and is why it is rarely used now.
What this interaction means in plain words
Edoxaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of ADP-receptor platelet inhibition and factor Xa inhibition, with possible added thrombocytopenia from ticlopidine.
What to do
Avoid if possible and use clopidogrel instead if an antiplatelet is needed. If given together, monitor blood counts and for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Edoxaban and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Edoxaban with Ticlopidine?
MediHelp rates the interaction as major. Edoxaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits platelet aggregation, and with edoxaban the bleeding risk rises. Ticlopidine also carries a risk of blood dyscrasias such as neutropenia and thrombocytopenia, which may further worsen bleeding and is why it is rarely used now.
How serious is the interaction between Edoxaban and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use clopidogrel instead if an antiplatelet is needed. If given together, monitor blood counts and for bleeding.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
