Drug interactions
Edoxaban + Tucatinib
Severity: Moderate
Edoxaban and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits intestinal P-glycoprotein and may raise edoxaban plasma exposure. Higher edoxaban levels can increase the risk of bleeding, particularly in patients with renal impairment or low body weight.
What this interaction means in plain words
Edoxaban and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein-mediated efflux of edoxaban, increasing its absorption and reducing its elimination.
What to do
Monitor for signs of bleeding and reassess renal function and body weight when starting tucatinib in patients on edoxaban. Consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Edoxaban with Tucatinib?
MediHelp rates the interaction as moderate. Edoxaban and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits intestinal P-glycoprotein and may raise edoxaban plasma exposure. Higher edoxaban levels can increase the risk of bleeding, particularly in patients with renal impairment or low body weight.
How serious is the interaction between Edoxaban and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and reassess renal function and body weight when starting tucatinib in patients on edoxaban. Consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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