Drug interactions
Elagolix + Eslicarbazepine
Severity: Moderate
Elagolix and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is metabolized by CYP3A4, and its labeling advises that moderate or strong inducers can lower its levels. Eslicarbazepine may therefore reduce its efficacy for endometriosis pain or heavy menstrual bleeding.
What this interaction means in plain words
Elagolix and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Eslicarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by eslicarbazepine increases elagolix clearance.
What to do
Monitor symptom control and consider an alternative antiseizure drug if efficacy declines. Elagolix may not be fully effective for contraception, so use a non-hormonal contraceptive method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Eslicarbazepine?
MediHelp rates the interaction as moderate. Elagolix and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is metabolized by CYP3A4, and its labeling advises that moderate or strong inducers can lower its levels. Eslicarbazepine may therefore reduce its efficacy for endometriosis pain or heavy menstrual bleeding.
How serious is the interaction between Elagolix and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider an alternative antiseizure drug if efficacy declines. Elagolix may not be fully effective for contraception, so use a non-hormonal contraceptive method.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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