Drug interactions
Elagolix + Ivabradine
Severity: Minor
Elagolix and Ivabradine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A inducer and may lower ivabradine concentrations. Reduced exposure could blunt heart rate lowering and weaken symptom control in angina or heart failure.
What this interaction means in plain words
Elagolix and Ivabradine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Ivabradine belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4, increasing the metabolism of ivabradine.
What to do
Monitor resting heart rate and clinical response after starting or stopping elagolix. Adjust the ivabradine dose within the labeled range if heart rate control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ivabradine?
MediHelp rates the interaction as minor. Elagolix and Ivabradine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A inducer and may lower ivabradine concentrations. Reduced exposure could blunt heart rate lowering and weaken symptom control in angina or heart failure.
How serious is the interaction between Elagolix and Ivabradine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor resting heart rate and clinical response after starting or stopping elagolix. Adjust the ivabradine dose within the labeled range if heart rate control is lost.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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