Drug interactions
Elagolix + Liposomal doxorubicin
Severity: Minor
Elagolix and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits P-gp and weakly to moderately induces CYP3A4, so effects on doxorubicin could go either way. Net impact is uncertain and probably small. Elagolix is used for endometriosis, so co-use with chemotherapy is uncommon.
What this interaction means in plain words
Elagolix and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Liposomal doxorubicin belongs to Oncology.
Why it happens
Elagolix inhibits P-gp and weakly to moderately induces CYP3A4, with opposing effects on doxorubicin exposure.
What to do
No empiric adjustment; monitor doxorubicin response and toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Elagolix and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix inhibits P-gp and weakly to moderately induces CYP3A4, so effects on doxorubicin could go either way. Net impact is uncertain and probably small. Elagolix is used for endometriosis, so co-use with chemotherapy is uncommon.
How serious is the interaction between Elagolix and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment; monitor doxorubicin response and toxicity.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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