Drug interactions
Elagolix + Lovastatin
Severity: Moderate
Elagolix and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower lovastatin exposure, reducing lipid-lowering effect. It also inhibits P-gp and OATP1B1, which could increase statin exposure, so the net effect is uncertain.
What this interaction means in plain words
Elagolix and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Lovastatin belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4 while inhibiting P-gp and OATP1B1, with opposing effects on lovastatin exposure.
What to do
Monitor lipid response and for muscle symptoms; adjust the lovastatin dose according to response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Lovastatin?
MediHelp rates the interaction as moderate. Elagolix and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower lovastatin exposure, reducing lipid-lowering effect. It also inhibits P-gp and OATP1B1, which could increase statin exposure, so the net effect is uncertain.
How serious is the interaction between Elagolix and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and for muscle symptoms; adjust the lovastatin dose according to response and tolerability.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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