Drug interactions
Elagolix + Mefloquine
Severity: Moderate
Elagolix and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower mefloquine concentrations. Reduced exposure could compromise malaria prevention or treatment.
What this interaction means in plain words
Elagolix and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Mefloquine belongs to Anti Parasitic.
Why it happens
Elagolix induces CYP3A4, accelerating mefloquine metabolism.
What to do
Monitor for reduced antimalarial efficacy and consider an alternative antimalarial agent in prophylaxis settings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elagolix and Mefloquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Mefloquine?
MediHelp rates the interaction as moderate. Elagolix and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower mefloquine concentrations. Reduced exposure could compromise malaria prevention or treatment.
How serious is the interaction between Elagolix and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimalarial efficacy and consider an alternative antimalarial agent in prophylaxis settings.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
