Drug interactions
Elagolix + Norethisterone
Severity: Moderate
Elagolix and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A inducer and may modestly lower norethisterone exposure. Efficacy of hormonal add-back therapy or contraception could be reduced, and elagolix itself is not contraceptive.
What this interaction means in plain words
Elagolix and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Norethisterone belongs to Endocrine.
Why it happens
Weak-to-moderate CYP3A4 induction by elagolix increases norethisterone metabolism.
What to do
Monitor for loss of norethisterone effect and use effective non-hormonal contraception during treatment. Adjust add-back therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Norethisterone?
MediHelp rates the interaction as moderate. Elagolix and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A inducer and may modestly lower norethisterone exposure. Efficacy of hormonal add-back therapy or contraception could be reduced, and elagolix itself is not contraceptive.
How serious is the interaction between Elagolix and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of norethisterone effect and use effective non-hormonal contraception during treatment. Adjust add-back therapy if needed.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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