Drug interactions
Elagolix + Omeprazole
Severity: Minor
Elagolix and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix weakly inhibits CYP2C19 and induces CYP3A4, which may modestly alter omeprazole exposure. At usual omeprazole doses the change is generally not clinically important.
What this interaction means in plain words
Elagolix and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition and CYP3A4 induction by elagolix alter omeprazole metabolism.
What to do
No adjustment is needed for omeprazole 40 mg/day or less. With higher doses, consider dose reduction and monitor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Omeprazole?
MediHelp rates the interaction as minor. Elagolix and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix weakly inhibits CYP2C19 and induces CYP3A4, which may modestly alter omeprazole exposure. At usual omeprazole doses the change is generally not clinically important.
How serious is the interaction between Elagolix and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for omeprazole 40 mg/day or less. With higher doses, consider dose reduction and monitor response.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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