Drug interactions
Elagolix + Paliperidone
Severity: Minor
Elagolix and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits intestinal P-glycoprotein, which may raise exposure to paliperidone, a P-glycoprotein substrate. Higher paliperidone levels could increase adverse effects such as QT prolongation, sedation and extrapyramidal symptoms. The effect is expected to be modest.
What this interaction means in plain words
Elagolix and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Paliperidone belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux, which increases paliperidone absorption.
What to do
Monitor for adverse effects of paliperidone such as sedation, extrapyramidal symptoms and orthostasis. Reduce the paliperidone dose if these effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Paliperidone?
MediHelp rates the interaction as minor. Elagolix and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix inhibits intestinal P-glycoprotein, which may raise exposure to paliperidone, a P-glycoprotein substrate. Higher paliperidone levels could increase adverse effects such as QT prolongation, sedation and extrapyramidal symptoms. The effect is expected to be modest.
How serious is the interaction between Elagolix and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of paliperidone such as sedation, extrapyramidal symptoms and orthostasis. Reduce the paliperidone dose if these effects emerge.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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