Drug interactions
Elagolix + Pravastatin
Severity: Minor
Elagolix and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix can inhibit intestinal P-glycoprotein and may modestly raise pravastatin exposure. The clinical effect is expected to be small, but higher statin levels could increase the chance of muscle-related adverse effects.
What this interaction means in plain words
Elagolix and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Pravastatin belongs to Cardiovascular.
Why it happens
Elagolix inhibits P-glycoprotein efflux and may also affect OATP-mediated uptake, slightly increasing pravastatin absorption.
What to do
No routine dose change is needed; ask patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Pravastatin?
MediHelp rates the interaction as minor. Elagolix and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix can inhibit intestinal P-glycoprotein and may modestly raise pravastatin exposure. The clinical effect is expected to be small, but higher statin levels could increase the chance of muscle-related adverse effects.
How serious is the interaction between Elagolix and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; ask patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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