Drug interactions
Elagolix + Ribociclib
Severity: Moderate
Elagolix and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer, which may lower ribociclib concentrations and reduce its antitumor effect. Ribociclib may in turn raise elagolix exposure. Elagolix is generally used in non-oncology settings, so concurrent use is uncommon.
What this interaction means in plain words
Elagolix and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Elagolix induces CYP3A4, lowering ribociclib exposure, while ribociclib inhibits CYP3A4 and may raise elagolix levels.
What to do
Review whether elagolix is needed; if combined, monitor for reduced ribociclib efficacy and elagolix adverse effects such as bone loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ribociclib?
MediHelp rates the interaction as moderate. Elagolix and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer, which may lower ribociclib concentrations and reduce its antitumor effect. Ribociclib may in turn raise elagolix exposure. Elagolix is generally used in non-oncology settings, so concurrent use is uncommon.
How serious is the interaction between Elagolix and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether elagolix is needed; if combined, monitor for reduced ribociclib efficacy and elagolix adverse effects such as bone loss.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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