Drug interactions
Elagolix + Rimegepant
Severity: Moderate
Elagolix and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix has mixed effects, weakly inducing CYP3A4 while inhibiting P-glycoprotein, so rimegepant exposure may change unpredictably. Both reduced efficacy and increased adverse effects are possible.
What this interaction means in plain words
Elagolix and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Rimegepant belongs to Central Nervous System.
Why it happens
Elagolix induces CYP3A4 and inhibits P-glycoprotein, with opposing effects on rimegepant exposure.
What to do
Avoid the combination if possible. If used, monitor for tolerability and efficacy and avoid repeat rimegepant doses within 48 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Rimegepant?
MediHelp rates the interaction as moderate. Elagolix and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix has mixed effects, weakly inducing CYP3A4 while inhibiting P-glycoprotein, so rimegepant exposure may change unpredictably. Both reduced efficacy and increased adverse effects are possible.
How serious is the interaction between Elagolix and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor for tolerability and efficacy and avoid repeat rimegepant doses within 48 hours.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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