Drug interactions
Elagolix + Rivaroxaban
Severity: Minor
Elagolix and Rivaroxaban: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A inducer and may modestly reduce rivaroxaban concentrations. The clinical effect is likely small but could slightly reduce anticoagulant protection.
What this interaction means in plain words
Elagolix and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Rivaroxaban belongs to Cardiovascular.
Why it happens
Elagolix induces CYP3A4, increasing rivaroxaban metabolism.
What to do
No routine dose change is needed; monitor for clinical signs of thrombosis during longer co-therapy. Reassess anticoagulant choice if breakthrough events occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Rivaroxaban?
MediHelp rates the interaction as minor. Elagolix and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A inducer and may modestly reduce rivaroxaban concentrations. The clinical effect is likely small but could slightly reduce anticoagulant protection.
How serious is the interaction between Elagolix and Rivaroxaban?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for clinical signs of thrombosis during longer co-therapy. Reassess anticoagulant choice if breakthrough events occur.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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