Drug interactions
Elagolix + Saxagliptin
Severity: Minor
Elagolix and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and also a P-gp inhibitor, so effects on saxagliptin could go in either direction. Induction may lower exposure to saxagliptin and its active metabolite, while P-gp inhibition may raise it.
What this interaction means in plain words
Elagolix and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Saxagliptin belongs to Endocrine.
Why it happens
Mixed effect: CYP3A4 induction by elagolix versus P-gp inhibition, with net impact uncertain.
What to do
No empirical dose change is needed; monitor glycemic control after starting or stopping elagolix.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Saxagliptin?
MediHelp rates the interaction as minor. Elagolix and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and also a P-gp inhibitor, so effects on saxagliptin could go in either direction. Induction may lower exposure to saxagliptin and its active metabolite, while P-gp inhibition may raise it.
How serious is the interaction between Elagolix and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor glycemic control after starting or stopping elagolix.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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