Drug interactions
Elagolix + Voriconazole
Severity: Moderate
Elagolix and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises elagolix exposure, which increases the risk of dose-related effects such as bone mineral density loss and hepatic effects. Elagolix may modestly affect voriconazole through weak CYP2C19 inhibition and CYP3A induction.
What this interaction means in plain words
Elagolix and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and reduces elagolix clearance; elagolix is a weak CYP2C19 inhibitor and a weak-to-moderate CYP3A inducer.
What to do
Limit elagolix to the reduced dose and shorter duration recommended in labeling when used with strong CYP3A inhibitors, and monitor for voriconazole efficacy and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Voriconazole?
MediHelp rates the interaction as moderate. Elagolix and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises elagolix exposure, which increases the risk of dose-related effects such as bone mineral density loss and hepatic effects. Elagolix may modestly affect voriconazole through weak CYP2C19 inhibition and CYP3A induction.
How serious is the interaction between Elagolix and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit elagolix to the reduced dose and shorter duration recommended in labeling when used with strong CYP3A inhibitors, and monitor for voriconazole efficacy and toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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