Drug interactions
Eletriptan + Fedratinib
Severity: Moderate
Eletriptan and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase eletriptan exposure. This increases the risk of dose-related triptan adverse effects, such as blood pressure elevation and chest symptoms.
What this interaction means in plain words
Eletriptan and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated eletriptan metabolism.
What to do
Use the lowest effective eletriptan dose and monitor blood pressure and adverse effects. Consider a non-CYP3A4 triptan if the combination is needed regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Eletriptan with Fedratinib?
MediHelp rates the interaction as moderate. Eletriptan and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase eletriptan exposure. This increases the risk of dose-related triptan adverse effects, such as blood pressure elevation and chest symptoms.
How serious is the interaction between Eletriptan and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and monitor blood pressure and adverse effects. Consider a non-CYP3A4 triptan if the combination is needed regularly.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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