Drug interactions
Eletriptan + Fenfluramine
Severity: Moderate
Eletriptan and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so using them together may raise the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, diarrhea and muscle rigidity.
What this interaction means in plain words
Eletriptan and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism by eletriptan and serotonin release by fenfluramine.
What to do
Monitor for signs of serotonin syndrome, especially after starting or increasing doses. Stop one or both agents if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Eletriptan with Fenfluramine?
MediHelp rates the interaction as moderate. Eletriptan and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so using them together may raise the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, diarrhea and muscle rigidity.
How serious is the interaction between Eletriptan and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially after starting or increasing doses. Stop one or both agents if symptoms develop.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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