Drug interactions
Eletriptan + Gepirone
Severity: Moderate
Eletriptan and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a serotonin 5-HT1A agonist antidepressant, and combining it with a triptan may increase serotonergic activity. This could lead to serotonin syndrome, although the reported risk with triptans is low.
What this interaction means in plain words
Eletriptan and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic pharmacodynamic effects at 5-HT receptors.
What to do
Monitor for serotonin syndrome, particularly when starting or raising doses. Discontinue one or both drugs if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Eletriptan with Gepirone?
MediHelp rates the interaction as moderate. Eletriptan and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is a serotonin 5-HT1A agonist antidepressant, and combining it with a triptan may increase serotonergic activity. This could lead to serotonin syndrome, although the reported risk with triptans is low.
How serious is the interaction between Eletriptan and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, particularly when starting or raising doses. Discontinue one or both drugs if symptoms occur.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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