Drug interactions
Eletriptan + Levoketoconazole
Severity: Contraindicated
Eletriptan and Levoketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can greatly increase eletriptan levels, raising the risk of vasoconstrictive and hypertensive toxicity. Eletriptan is contraindicated with strong CYP3A4 inhibitors.
What this interaction means in plain words
Eletriptan and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4-mediated metabolism of eletriptan.
What to do
Do not give eletriptan during or within 72 hours of levoketoconazole. Use a triptan not metabolized mainly by CYP3A4.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Eletriptan with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Eletriptan and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor and can greatly increase eletriptan levels, raising the risk of vasoconstrictive and hypertensive toxicity. Eletriptan is contraindicated with strong CYP3A4 inhibitors.
How serious is the interaction between Eletriptan and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give eletriptan during or within 72 hours of levoketoconazole. Use a triptan not metabolized mainly by CYP3A4.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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