Drug interactions
Eletriptan + Mirtazapine
Severity: Moderate
Eletriptan and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with serotonergic antidepressants carry a theoretical risk of serotonin syndrome. Mirtazapine has weak serotonin reuptake effects, so reported risk is low, but the combination is flagged in labeling for serotonergic drugs.
What this interaction means in plain words
Eletriptan and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity via 5-HT1B/1D agonism and mirtazapine 5-HT effects.
What to do
Counsel patients to report agitation, tremor, sweating, fever or diarrhea after a triptan dose. Stop both agents and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Mirtazapine?
MediHelp rates the interaction as moderate. Eletriptan and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with serotonergic antidepressants carry a theoretical risk of serotonin syndrome. Mirtazapine has weak serotonin reuptake effects, so reported risk is low, but the combination is flagged in labeling for serotonergic drugs.
How serious is the interaction between Eletriptan and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, fever or diarrhea after a triptan dose. Stop both agents and treat if serotonin syndrome is suspected.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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