Drug interactions
Eletriptan + Ondansetron
Severity: Minor
Eletriptan and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonin pathways, so there is a theoretical risk of serotonin syndrome when used together. Documented cases are rare and ondansetron is often used for migraine-related nausea.
What this interaction means in plain words
Eletriptan and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Theoretical additive serotonergic effect; the clinical relevance of 5-HT3 antagonism is not well established.
What to do
No routine change is needed; advise patients to report agitation, tremor, sweating or fever. Stop both drugs and seek care if serotonin syndrome is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Ondansetron?
MediHelp rates the interaction as minor. Eletriptan and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on serotonin pathways, so there is a theoretical risk of serotonin syndrome when used together. Documented cases are rare and ondansetron is often used for migraine-related nausea.
How serious is the interaction between Eletriptan and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report agitation, tremor, sweating or fever. Stop both drugs and seek care if serotonin syndrome is suspected.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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