Drug interactions
Eletriptan + Ozanimod
Severity: Moderate
Eletriptan and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and the labeling warns of hypertensive reactions with drugs affecting norepinephrine or serotonin. Eletriptan adds vasoconstrictive and serotonergic effects. The interaction is mostly theoretical.
What this interaction means in plain words
Eletriptan and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by an ozanimod metabolite adds to the monoaminergic and pressor effects of the triptan.
What to do
Monitor blood pressure and heart rate with concurrent use. Advise the patient to report severe headache or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Eletriptan with Ozanimod?
MediHelp rates the interaction as moderate. Eletriptan and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and the labeling warns of hypertensive reactions with drugs affecting norepinephrine or serotonin. Eletriptan adds vasoconstrictive and serotonergic effects. The interaction is mostly theoretical.
How serious is the interaction between Eletriptan and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate with concurrent use. Advise the patient to report severe headache or palpitations.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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