Drug interactions
Eletriptan + Stiripentol
Severity: Moderate
Eletriptan and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-gp, so the net effect on eletriptan exposure is unpredictable. Exposure may rise, with more adverse effects, or fall, with reduced efficacy.
What this interaction means in plain words
Eletriptan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-gp inhibition by stiripentol alters eletriptan clearance.
What to do
Monitor for changes in eletriptan efficacy or adverse effects and adjust the dose accordingly, or use an alternative triptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Eletriptan with Stiripentol?
MediHelp rates the interaction as moderate. Eletriptan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-gp, so the net effect on eletriptan exposure is unpredictable. Exposure may rise, with more adverse effects, or fall, with reduced efficacy.
How serious is the interaction between Eletriptan and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for changes in eletriptan efficacy or adverse effects and adjust the dose accordingly, or use an alternative triptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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