Drug interactions
Eletriptan + Tramadol
Severity: Moderate
Eletriptan and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and tramadol both act on serotonergic pathways, and combined use has been associated with serotonin syndrome. Tramadol also lowers the seizure threshold. The absolute risk appears low but is clinically important.
What this interaction means in plain words
Eletriptan and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive serotonergic activity (5-HT1B/1D agonism with tramadol serotonin reuptake inhibition).
What to do
Monitor for agitation, tremor, diaphoresis, hyperthermia and clonus, and stop both drugs if serotonin syndrome is suspected. Consider a non-serotonergic analgesic for headache.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Tramadol?
MediHelp rates the interaction as moderate. Eletriptan and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans and tramadol both act on serotonergic pathways, and combined use has been associated with serotonin syndrome. Tramadol also lowers the seizure threshold. The absolute risk appears low but is clinically important.
How serious is the interaction between Eletriptan and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, diaphoresis, hyperthermia and clonus, and stop both drugs if serotonin syndrome is suspected. Consider a non-serotonergic analgesic for headache.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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