Drug interactions
Eliglustat + Ivermectin
Severity: Minor
Eliglustat and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits intestinal P-glycoprotein and may raise exposure to ivermectin, which is a P-gp substrate. Ivermectin has a wide safety margin, so clinically important toxicity is unlikely, but higher levels could increase neurological adverse effects.
What this interaction means in plain words
Eliglustat and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Ivermectin belongs to Anti Parasitic.
Why it happens
Eliglustat inhibits P-glycoprotein efflux, increasing ivermectin absorption and reducing its efflux from tissues.
What to do
No routine dose change is needed for standard ivermectin courses. Monitor for dizziness, neurological symptoms or other ivermectin adverse effects if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Ivermectin?
MediHelp rates the interaction as minor. Eliglustat and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits intestinal P-glycoprotein and may raise exposure to ivermectin, which is a P-gp substrate. Ivermectin has a wide safety margin, so clinically important toxicity is unlikely, but higher levels could increase neurological adverse effects.
How serious is the interaction between Eliglustat and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for standard ivermectin courses. Monitor for dizziness, neurological symptoms or other ivermectin adverse effects if used together.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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