Drug interactions
Eliglustat + Prochlorperazine
Severity: Moderate
Eliglustat and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high exposures, and prochlorperazine can also prolong the QT interval. Together they may raise the risk of torsades de pointes, particularly in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Eliglustat and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; prochlorperazine may also inhibit CYP2D6, increasing eliglustat exposure.
What to do
Obtain an ECG and correct electrolytes before and during combined use. Avoid the combination in patients with long QT syndrome or significant cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Prochlorperazine?
MediHelp rates the interaction as moderate. Eliglustat and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong the PR, QRS and QT intervals at high exposures, and prochlorperazine can also prolong the QT interval. Together they may raise the risk of torsades de pointes, particularly in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Eliglustat and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes before and during combined use. Avoid the combination in patients with long QT syndrome or significant cardiac disease.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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