Drug interactions
Eliglustat + Ticlopidine
Severity: Major
Eliglustat and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2D6 and raises eliglustat concentrations, increasing the risk of PR, QRS and QT interval prolongation and arrhythmia. Ticlopidine also inhibits CYP2C19, though it is not a major eliglustat pathway.
What this interaction means in plain words
Eliglustat and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Ticlopidine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6 by ticlopidine decreases eliglustat metabolism.
What to do
Reduce eliglustat dose per labeling for CYP2D6 inhibitors, and avoid if a CYP3A inhibitor is also given. Monitor ECG and consider an alternative antiplatelet.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Ticlopidine?
MediHelp rates the interaction as major. Eliglustat and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits CYP2D6 and raises eliglustat concentrations, increasing the risk of PR, QRS and QT interval prolongation and arrhythmia. Ticlopidine also inhibits CYP2C19, though it is not a major eliglustat pathway.
How serious is the interaction between Eliglustat and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eliglustat dose per labeling for CYP2D6 inhibitors, and avoid if a CYP3A inhibitor is also given. Monitor ECG and consider an alternative antiplatelet.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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