Drug interactions
Eluxadoline + Leflunomide
Severity: Minor
Eluxadoline and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits BCRP and may raise exposure to BCRP substrates. Teriflunomide, the active metabolite of leflunomide, may be affected, increasing its adverse effects.
What this interaction means in plain words
Eluxadoline and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Leflunomide belongs to Musculoskeletal.
Why it happens
Eluxadoline inhibits BCRP, reducing efflux of teriflunomide.
What to do
No routine adjustment; monitor liver enzymes and blood counts as part of standard leflunomide monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Leflunomide?
MediHelp rates the interaction as minor. Eluxadoline and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline inhibits BCRP and may raise exposure to BCRP substrates. Teriflunomide, the active metabolite of leflunomide, may be affected, increasing its adverse effects.
How serious is the interaction between Eluxadoline and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor liver enzymes and blood counts as part of standard leflunomide monitoring.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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