Drug interactions
Eluxadoline + Ticlopidine
Severity: Minor
Eluxadoline and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline's metabolism is incompletely characterized, and CYP2C19 inhibition by ticlopidine might raise exposure. No clear clinical effect has been demonstrated.
What this interaction means in plain words
Eluxadoline and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible reduction of eluxadoline clearance through CYP2C19 inhibition; not firmly established.
What to do
Monitor for constipation, nausea or abdominal pain, and reduce eluxadoline if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Ticlopidine?
MediHelp rates the interaction as minor. Eluxadoline and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline's metabolism is incompletely characterized, and CYP2C19 inhibition by ticlopidine might raise exposure. No clear clinical effect has been demonstrated.
How serious is the interaction between Eluxadoline and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, nausea or abdominal pain, and reduce eluxadoline if adverse effects occur.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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