Drug interactions
Empagliflozin + Eprosartan-hydrochlorothiazide
Severity: Moderate
Empagliflozin and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin increases urinary glucose and fluid loss, which adds to the diuretic effect of hydrochlorothiazide and the renal effects of eprosartan. This can result in volume depletion, hypotension and acute kidney injury, especially in the elderly.
What this interaction means in plain words
Empagliflozin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive osmotic diuresis and natriuresis, with reduced glomerular pressure from angiotensin receptor blockade.
What to do
Assess volume status and renal function before starting empagliflozin and monitor afterwards. Reduce the thiazide dose if volume depletion or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Empagliflozin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin increases urinary glucose and fluid loss, which adds to the diuretic effect of hydrochlorothiazide and the renal effects of eprosartan. This can result in volume depletion, hypotension and acute kidney injury, especially in the elderly.
How serious is the interaction between Empagliflozin and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting empagliflozin and monitor afterwards. Reduce the thiazide dose if volume depletion or hypotension occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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