Drug interactions
Empagliflozin + Gliclazide
Severity: Moderate
Empagliflozin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin combined with a sulfonylurea such as gliclazide raises the incidence of hypoglycemia compared with the sulfonylurea alone. The two drugs lower glucose by different mechanisms and their effects add up.
What this interaction means in plain words
Empagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Gliclazide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea insulin secretion plus SGLT2-mediated urinary glucose excretion.
What to do
Consider a lower gliclazide dose when empagliflozin is started and monitor blood glucose, especially in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Gliclazide?
MediHelp rates the interaction as moderate. Empagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin combined with a sulfonylurea such as gliclazide raises the incidence of hypoglycemia compared with the sulfonylurea alone. The two drugs lower glucose by different mechanisms and their effects add up.
How serious is the interaction between Empagliflozin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower gliclazide dose when empagliflozin is started and monitor blood glucose, especially in older or renally impaired patients.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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