Drug interactions
Empagliflozin + Glyburide-metformin
Severity: Moderate
Empagliflozin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds glucose lowering to a sulfonylurea and increases the risk of hypoglycemia. Volume depletion and, rarely, ketoacidosis are additional concerns with the SGLT2 inhibitor.
What this interaction means in plain words
Empagliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects: glyburide stimulates insulin secretion while empagliflozin promotes urinary glucose excretion independently of insulin.
What to do
Consider lowering the glyburide dose when empagliflozin is started and counsel the patient on hypoglycemia symptoms. Monitor blood glucose and hydration status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Empagliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds glucose lowering to a sulfonylurea and increases the risk of hypoglycemia. Volume depletion and, rarely, ketoacidosis are additional concerns with the SGLT2 inhibitor.
How serious is the interaction between Empagliflozin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when empagliflozin is started and counsel the patient on hypoglycemia symptoms. Monitor blood glucose and hydration status.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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