Drug interactions
Empagliflozin + Hydrochlorothiazide-valsartan
Severity: Moderate
Empagliflozin and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has a diuretic effect, and adding it to hydrochlorothiazide and an ARB increases the risk of volume depletion, hypotension and transient decline in kidney function. The risk is higher in elderly patients and those with low baseline blood pressure.
What this interaction means in plain words
Empagliflozin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive osmotic diuresis and natriuresis from SGLT2 inhibition and thiazide action, with ARB reducing compensatory hemodynamic responses.
What to do
Assess volume status, blood pressure and renal function before and after starting empagliflozin, and consider lowering the diuretic dose if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Empagliflozin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has a diuretic effect, and adding it to hydrochlorothiazide and an ARB increases the risk of volume depletion, hypotension and transient decline in kidney function. The risk is higher in elderly patients and those with low baseline blood pressure.
How serious is the interaction between Empagliflozin and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status, blood pressure and renal function before and after starting empagliflozin, and consider lowering the diuretic dose if volume depletion develops.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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