Drug interactions
Empagliflozin + Insulin glargine-lixisenatide
Severity: Moderate
Empagliflozin and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding empagliflozin to insulin-based therapy increases the risk of hypoglycemia because the glucose-lowering effects are additive. The insulin dose may need to be reduced.
What this interaction means in plain words
Empagliflozin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Additive glucose lowering: SGLT2 inhibition causes insulin-independent urinary glucose loss on top of insulin and GLP-1 effects.
What to do
Consider reducing the insulin dose when starting empagliflozin and monitor blood glucose. Also watch for ketoacidosis if insulin is cut substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Empagliflozin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding empagliflozin to insulin-based therapy increases the risk of hypoglycemia because the glucose-lowering effects are additive. The insulin dose may need to be reduced.
How serious is the interaction between Empagliflozin and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting empagliflozin and monitor blood glucose. Also watch for ketoacidosis if insulin is cut substantially.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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