Drug interactions
Empagliflozin + Metformin-repaglinide
Severity: Moderate
Empagliflozin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin lowers blood glucose through urinary glucose excretion, which adds to the glucose-lowering effect of metformin and repaglinide. Metformin carries little hypoglycemia risk, but the repaglinide component can cause hypoglycemia, particularly with reduced food intake.
What this interaction means in plain words
Empagliflozin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering, with the insulin secretagogue (repaglinide) responsible for the hypoglycemia risk.
What to do
Monitor blood glucose when starting empagliflozin and consider lowering the repaglinide dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms and on volume status and sick-day rules.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Empagliflozin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin lowers blood glucose through urinary glucose excretion, which adds to the glucose-lowering effect of metformin and repaglinide. Metformin carries little hypoglycemia risk, but the repaglinide component can cause hypoglycemia, particularly with reduced food intake.
How serious is the interaction between Empagliflozin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting empagliflozin and consider lowering the repaglinide dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms and on volume status and sick-day rules.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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