Drug interactions
Empagliflozin + Nateglinide
Severity: Moderate
Empagliflozin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds insulin-independent glucose lowering to the insulin release triggered by nateglinide. The combination raises the risk of hypoglycemia, especially with skipped meals.
What this interaction means in plain words
Empagliflozin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from insulin secretion plus renal glucose excretion.
What to do
Monitor blood glucose when empagliflozin is added and educate the patient about hypoglycemia. Lower the nateglinide dose if low glucose readings occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Nateglinide?
MediHelp rates the interaction as moderate. Empagliflozin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds insulin-independent glucose lowering to the insulin release triggered by nateglinide. The combination raises the risk of hypoglycemia, especially with skipped meals.
How serious is the interaction between Empagliflozin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when empagliflozin is added and educate the patient about hypoglycemia. Lower the nateglinide dose if low glucose readings occur.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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