Drug interactions
Empagliflozin + Triamterene
Severity: Moderate
Empagliflozin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has osmotic diuretic effects that add to those of triamterene. This can cause volume depletion, hypotension and acute kidney injury, particularly in elderly or renally impaired patients.
What this interaction means in plain words
Empagliflozin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Additive diuresis and natriuresis from SGLT2 inhibition and distal sodium channel blockade.
What to do
Assess volume status and renal function before and after starting empagliflozin, and consider reducing the diuretic dose if volume depletion occurs. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Triamterene?
MediHelp rates the interaction as moderate. Empagliflozin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has osmotic diuretic effects that add to those of triamterene. This can cause volume depletion, hypotension and acute kidney injury, particularly in elderly or renally impaired patients.
How serious is the interaction between Empagliflozin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting empagliflozin, and consider reducing the diuretic dose if volume depletion occurs. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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